we recently got a new machine with enough CPUs and memory to run cisTEM on large datasets (32 CPUs, 512 GB RAM).
I tried to do movie alignment on 500 micrographs (K2, super res) but it seems to be going very slowly.
When the job is first submitted, the GUI freezes for a few minutes. After 10-15 minutes it starts to show periodic updates on the progress, but the initial estimates are ~22 hours for 500 micrographs.
Is this normal?
When I submit a single movie for alignment, the GUI still freezes. After a minute or two, it refreshes and the job is done.
Where could we be encountering problems? Or, is this typical behaviour?